早卵泡期长方案与拮抗剂方案治疗卵巢储备功能下降年轻患者的效果比较(1)
[摘要]目的 比較早卵泡期长方案与拮抗剂方案治疗卵巢储备功能下降(DOR)年轻患者的效果。方法 回顾性分析2016年1月～2017年6月我院收治的272例行体外受精/卵胞浆内单精子注射(IVF/ICSI)治疗的35岁以下DOR患者的临床资料，按照促排卵方案的不同将其分为A组(112例)和B组(160例)。A组患者采用早卵泡期长方案，B组患者采用拮抗剂方案。比较两组患者的促排卵效果和妊娠结局，促排卵效果指标包括促性腺激素(Gn)使用总量、人绒毛膜促性腺激素(HCG)日黄体生成素(LH)、HCG日内膜厚度、获卵数、优质胚胎率及移植胚胎数，以临床妊娠率、种植率、活产率为妊娠结局的评价标准。结果 A组患者的Gn使用总量多于B组，HCG日LH水平低于B组，HCG日内膜厚度、获卵数、种植率、临床妊娠率及活产率均高于B组，差异有统计学意义(P<0.05)；两组患者的优质胚胎率、移植胚胎数比较，差异无统计学意义(P>0.05)。结论 对于DOR的年轻患者，早卵泡期长方案的效果优于拮抗剂方案，更适合作为超促排卵备选方案。
[关键词]早卵泡期长方案；拮抗剂方案；卵巢储备功能下降；超促排卵
[中图分类号] R984 [文献标识码] A [文章编号] 1674-4721(2019)5(c)-0062-03
[Abstract] Objective To compare the effect of early follicular long-term regimen and antagonist regimen in the treatment of young patients with diminished ovarian reserve (DOR). Methods The clinical data of 272 cases of DOR patients under 35 years of age who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment from January 2016 to June 2017 in our hospital were retrospectively analyzed. According to the different ovulation induction regimens， the patients were divided into group A (112 cases) and group B (160 cases). The patients in the group A received early follicular long-term regimen， and the patients in the group B received antagonist regimen. The ovulation induction effect and pregnancy outcomes were compared between the two groups. The ovulation induction indicators included gonadotrophin (Gn) total use， luteinizing hormone (LH) in human chorionic gonadotropin (HCG) day， HCG endometrial thickness， number of eggs obtained， high quality embryo rate and number of transplanted embryos. The clinical pregnancy rate， implantation rate， and live birth rate were used as the evaluation criteria for pregnancy outcome. Results The total use of Gn in group A was more than that in group B， the level of LH in HCG day was lower than that in group B， the HCG endometrial thickness， number of eggs obtained， planting rate， clinical pregnancy rate and live birth rate were higher than those in group B， and the differences were statistically significant (P<0.05). There were no significant differences in the quality of embryo rate and the number of transplanted embryos between the two groups (P>0.05). Conclusion For young patients with DOR， the effect of the early follicular long-term regimen is superior to that of the antagonist regimen and it is more suitable as an alternative regimen for ovarian hyper-stimulation.
[Key words] Early follicular long-term regimen； Antagonist regimen； Diminished ovarian reserve； Ovarian hyper-stimulation, 百拇医药(郭岩文 郑娟 蔡嘉力)
[关键词]早卵泡期长方案；拮抗剂方案；卵巢储备功能下降；超促排卵
[中图分类号] R984 [文献标识码] A [文章编号] 1674-4721(2019)5(c)-0062-03
[Abstract] Objective To compare the effect of early follicular long-term regimen and antagonist regimen in the treatment of young patients with diminished ovarian reserve (DOR). Methods The clinical data of 272 cases of DOR patients under 35 years of age who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment from January 2016 to June 2017 in our hospital were retrospectively analyzed. According to the different ovulation induction regimens， the patients were divided into group A (112 cases) and group B (160 cases). The patients in the group A received early follicular long-term regimen， and the patients in the group B received antagonist regimen. The ovulation induction effect and pregnancy outcomes were compared between the two groups. The ovulation induction indicators included gonadotrophin (Gn) total use， luteinizing hormone (LH) in human chorionic gonadotropin (HCG) day， HCG endometrial thickness， number of eggs obtained， high quality embryo rate and number of transplanted embryos. The clinical pregnancy rate， implantation rate， and live birth rate were used as the evaluation criteria for pregnancy outcome. Results The total use of Gn in group A was more than that in group B， the level of LH in HCG day was lower than that in group B， the HCG endometrial thickness， number of eggs obtained， planting rate， clinical pregnancy rate and live birth rate were higher than those in group B， and the differences were statistically significant (P<0.05). There were no significant differences in the quality of embryo rate and the number of transplanted embryos between the two groups (P>0.05). Conclusion For young patients with DOR， the effect of the early follicular long-term regimen is superior to that of the antagonist regimen and it is more suitable as an alternative regimen for ovarian hyper-stimulation.
[Key words] Early follicular long-term regimen； Antagonist regimen； Diminished ovarian reserve； Ovarian hyper-stimulation, 百拇医药(郭岩文 郑娟 蔡嘉力)