血清淀粉样蛋白A、肝素结合蛋白与脓毒症严重程度的相关性分析(1)
[摘要]目的 探討血清淀粉样蛋白A(SAA)、肝素结合蛋白(HBP)与脓毒症严重程度的相关性。方法 选取2015年11月～2018年1月我院收治的120例脓毒症患者作为病例组，根据病情严重程度将患者分为脓毒症组(48例)、严重脓毒症组(40例)、脓毒性休克组(32例)。选取同期在我院进行体检的40例健康体检者作为对照组，比较各组的SAA与HBP水平，分析其与脓毒症严重程度的相关性。结果 病例组患者的血清SAA与HBP水平高于对照组，差异有统计学意义(P<0.05)；严重脓毒症组、脓毒性休克组的血清SAA与HBP水平高于脓毒症组，差异有统计学意义(P<0.05)；脓毒性休克组的血清SAA与HBP水平高于严重脓毒症组，差异有统计学意义(P<0.05)。Pearson相关性分析显示，血清SAA、HBP与脓毒症的严重程度呈正相关(r=0.752、0.794，P<0.05)。结论 血清SAA、HBP与脓毒症严重程度呈正相关，临床密切监测患者的血清SAA、HBP水平能够了解脓毒症的严重程度，值得临床推广应用。
[关键词]血清淀粉样蛋白A；肝素结合蛋白；脓毒症；相关性分析
[中图分类号] R363 [文献标识码] A [文章编号] 1674-4721(2018)5(c)-0127-03
Correlation analysis of serum amyloid A，heparin binding protein and the severity of sepsis
LI Shou-wei
Department of Clinical Laboratory，People′s Hospital of Yi′nan County in Shandong Province，Yi′nan 276000，China
[Abstract]Objective To explore the correlation between serum amyloid A (SAA)，heparin binding protein (HBP) and the severity of sepsis.Methods 120 cases of patients with sepsis who treated in our hospital from November 2015 to January 2018 were selected as the case group，and they were divided into the sepsis group (48 cases)，the severe sepsis group (40 cases) and the septic shock group (32 cases) according to the severity degree of the disease.At the same time，40 cases of health examination in our hospital were selected as the control group.The levels of SAA and HBP in the each group were compared and the correlation with the severity of sepsis was analyzed.Results The levels of serum SAA and HBP in the case group were higher than those in the control group，and the differences were statistically significant (P<0.05).The levels of serum SAA and HBP in the severe sepsis group and the septic shock group were higher than those in the sepsis group，and the differences were statistically significant (P<0.05).The levels of serum SAA and HBP in the septic shock group were higher than those in the severe sepsis group，and the differences were statistically significant (P<0.05).Pearson correlation analysis showed that serum SAA and HBP were positively correlated with the severity of sepsis (r=0.752，0.794，P<0.05).Conclusion The serum levels of SAA and HBP are positively correlated with the severity of sepsis.The level of serum SAA and HBP are closely monitored in patients with sepsis which can be used to understand the severity of sepsis，and it is worthy of clinical promotion and application.
[Key words]Serum amyloid A；Heparin binding protein；Sepsis；Correlation analysis, 百拇医药(李守玮)
[关键词]血清淀粉样蛋白A；肝素结合蛋白；脓毒症；相关性分析
[中图分类号] R363 [文献标识码] A [文章编号] 1674-4721(2018)5(c)-0127-03
Correlation analysis of serum amyloid A，heparin binding protein and the severity of sepsis
LI Shou-wei
Department of Clinical Laboratory，People′s Hospital of Yi′nan County in Shandong Province，Yi′nan 276000，China
[Abstract]Objective To explore the correlation between serum amyloid A (SAA)，heparin binding protein (HBP) and the severity of sepsis.Methods 120 cases of patients with sepsis who treated in our hospital from November 2015 to January 2018 were selected as the case group，and they were divided into the sepsis group (48 cases)，the severe sepsis group (40 cases) and the septic shock group (32 cases) according to the severity degree of the disease.At the same time，40 cases of health examination in our hospital were selected as the control group.The levels of SAA and HBP in the each group were compared and the correlation with the severity of sepsis was analyzed.Results The levels of serum SAA and HBP in the case group were higher than those in the control group，and the differences were statistically significant (P<0.05).The levels of serum SAA and HBP in the severe sepsis group and the septic shock group were higher than those in the sepsis group，and the differences were statistically significant (P<0.05).The levels of serum SAA and HBP in the septic shock group were higher than those in the severe sepsis group，and the differences were statistically significant (P<0.05).Pearson correlation analysis showed that serum SAA and HBP were positively correlated with the severity of sepsis (r=0.752，0.794，P<0.05).Conclusion The serum levels of SAA and HBP are positively correlated with the severity of sepsis.The level of serum SAA and HBP are closely monitored in patients with sepsis which can be used to understand the severity of sepsis，and it is worthy of clinical promotion and application.
[Key words]Serum amyloid A；Heparin binding protein；Sepsis；Correlation analysis, 百拇医药(李守玮)