2012年1月～2014年12月我院呼吸科头孢菌素类抗菌药物的应用分析(1)
[摘要] 目的 了解我院呼吸科头孢菌素类抗菌药物的应用情况，为临床合理用药提供参考依据。 方法 采用用药频度﹙DDDs﹚分析法，对我院呼吸科2012年1月～2014年12月头孢菌素类抗菌药物的销售金额、DDDs等进行排序和分析。 结果 近3年来，我院呼吸科应用头孢菌素类药物的销售金额总体呈上升趋势，DDDs基本持平。2012、2013年第一代头孢菌素占主流，2014年第二、三代头孢的DDDs远超于第一代头孢，其中第二代头孢的销售金额与DDDs居首。 结论 我院呼吸科头孢菌素抗菌药物的应用比较合理，但还需进一步规范，以控制或减缓细菌耐药性的发展速度，促进安全、有效、经济地应用此类药物。
[关键词] 呼吸科；头孢菌素；用药频度；销售金额；耐药性
[中图分类号] R969.3 [文献标识码] A [文章编号] 1674-4721(2016)01(b)-0118-04
Application analysis on cephalosporin antibacterial agents in pneumology department of our hospital from January 2012 to December 2014
GUO Xiao-ning1 HE Wei2 YANG Li-fu1
1.Department of Pharmacy，Affiliated Central Hospital of Shenyang Medical School，Shenyang 110024，China；2.Department of Pneumology，Affiliated Central Hospital of Shenyang Medical School，Shenyang 110024，China
[Abstract] Objective To explore the application situation of cephalosporins antibacterial agents in pneumology department of our hospital and to provide reference to clinical rational drug use. Methods Defined daily dose system (DDDs) was applied，and the sales amount and DDDs of cephalosporins used in pneumology department of our hospital from January 2012 to December 2014 were ranked and analyzed. Results In recent 3 years，the sales amount of cephalosporins used in pneumology department of our hospital was showed an increasing tendency，while DDDs nearly held the line.In 2012 and 2013，cephalosporins of generation 1 was the main aspect，while in 2014，DDDs of cephalosporin generation 2 and 3 was far more than generation 1，and the cephalosporins of generation 2 leaded the sales amount and DDDs. Conclusion The application of cephalosporins in pneumology department of our hospital is relatively reasonabl，but still need to further standardize，to contral or slow the development of bacterial drug resistance，and to facilitate the safety，effectivene and economical efficiency in use of cephalosporin.
[Key words] Department of pneumology；Cephalosporin；Defined daily dose system；Sale amount；Drug resistance
呼吸系统感染是呼吸科最为常见的疾病，目前临床多用β-内酰胺类、大环内酯类和喹诺酮类进行抗感染治疗。头孢菌素与青霉素类同为β-内酰胺类抗菌药物，均作为繁殖期杀菌剂。其通过抑制细菌细胞壁的生成而达到杀菌目的，头孢菌素类比青霉素类的抗菌谱更广、不良反应更低，尤其是对β-内酰胺酶稳定，是我院呼吸科主要抗感染用药。本研究对我院近3年来的头孢菌素类抗菌药物应用情况进行统计分析和评价，以期为临床抗菌药物的应用提供参考依据。
1 资料与方法
1.1 一般资料
从我院药品信息管理系统调取2012年1月～2014年12月呼吸科应用的头孢菌素类抗菌药物的基本信息、销售数量及金额等数据，再从院内感染资料库中提取同期细菌耐药性的监测数据。
1.2 方法
将药品数据输入Excel表，并对各项数据进行统计汇总，应用用药频度(DDDs)分析法及序号比(B/A)对数据进行分析。参照《新编药物学》(17版)和我省2012年修订的《抗菌药物临床应用分级管理目录》对头孢菌素类抗菌药物的品种(即第一、二、三、四代)进行分类统计，并根据原卫生部抗菌药物临床应用监测网确定药品的限定日剂量(defined daily dose，DDD)。DDDs=药物年销售总量/该药的DDD，DDDs值越大，说明该药的用药频率越大。B/A=药品销售金额排序/DDDs排序，其值接近1为好，反之较差[1]。, http://www.100md.com(郭晓宁 何巍 杨立夫)
[关键词] 呼吸科；头孢菌素；用药频度；销售金额；耐药性
[中图分类号] R969.3 [文献标识码] A [文章编号] 1674-4721(2016)01(b)-0118-04
Application analysis on cephalosporin antibacterial agents in pneumology department of our hospital from January 2012 to December 2014
GUO Xiao-ning1 HE Wei2 YANG Li-fu1
1.Department of Pharmacy，Affiliated Central Hospital of Shenyang Medical School，Shenyang 110024，China；2.Department of Pneumology，Affiliated Central Hospital of Shenyang Medical School，Shenyang 110024，China
[Abstract] Objective To explore the application situation of cephalosporins antibacterial agents in pneumology department of our hospital and to provide reference to clinical rational drug use. Methods Defined daily dose system (DDDs) was applied，and the sales amount and DDDs of cephalosporins used in pneumology department of our hospital from January 2012 to December 2014 were ranked and analyzed. Results In recent 3 years，the sales amount of cephalosporins used in pneumology department of our hospital was showed an increasing tendency，while DDDs nearly held the line.In 2012 and 2013，cephalosporins of generation 1 was the main aspect，while in 2014，DDDs of cephalosporin generation 2 and 3 was far more than generation 1，and the cephalosporins of generation 2 leaded the sales amount and DDDs. Conclusion The application of cephalosporins in pneumology department of our hospital is relatively reasonabl，but still need to further standardize，to contral or slow the development of bacterial drug resistance，and to facilitate the safety，effectivene and economical efficiency in use of cephalosporin.
[Key words] Department of pneumology；Cephalosporin；Defined daily dose system；Sale amount；Drug resistance
呼吸系统感染是呼吸科最为常见的疾病，目前临床多用β-内酰胺类、大环内酯类和喹诺酮类进行抗感染治疗。头孢菌素与青霉素类同为β-内酰胺类抗菌药物，均作为繁殖期杀菌剂。其通过抑制细菌细胞壁的生成而达到杀菌目的，头孢菌素类比青霉素类的抗菌谱更广、不良反应更低，尤其是对β-内酰胺酶稳定，是我院呼吸科主要抗感染用药。本研究对我院近3年来的头孢菌素类抗菌药物应用情况进行统计分析和评价，以期为临床抗菌药物的应用提供参考依据。
1 资料与方法
1.1 一般资料
从我院药品信息管理系统调取2012年1月～2014年12月呼吸科应用的头孢菌素类抗菌药物的基本信息、销售数量及金额等数据，再从院内感染资料库中提取同期细菌耐药性的监测数据。
1.2 方法
将药品数据输入Excel表，并对各项数据进行统计汇总，应用用药频度(DDDs)分析法及序号比(B/A)对数据进行分析。参照《新编药物学》(17版)和我省2012年修订的《抗菌药物临床应用分级管理目录》对头孢菌素类抗菌药物的品种(即第一、二、三、四代)进行分类统计，并根据原卫生部抗菌药物临床应用监测网确定药品的限定日剂量(defined daily dose，DDD)。DDDs=药物年销售总量/该药的DDD，DDDs值越大，说明该药的用药频率越大。B/A=药品销售金额排序/DDDs排序，其值接近1为好，反之较差[1]。, http://www.100md.com(郭晓宁 何巍 杨立夫)