能谱CT碘基图对胰腺癌生物治疗疗效的分析(1)
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[摘要] 目的 通过对胰腺癌患者生物治疗前、后行能谱CT增强扫描，探讨CT能谱成像对胰腺癌生物治疗疗效的价值。 方法 选取本院20例进行生物治疗的胰腺癌患者，均行能谱CT增强扫描，在宝石能谱成像浏览器(GSI viewer)软件的碘基图上测量治疗前、后肿瘤的碘含量，并进行数据分析及配对t检验。 结果 20例胰腺癌患者，生物治疗前肿瘤内兴趣区(ROI)碘含量为(3.05±0.42) g/L，治疗后ROI 碘含量为 (1.89±0.33) g/L，通过配对t检验，治疗后肿瘤内碘含量较治疗前降低，两组间的差别具有统计学意义(t = 19.19 P < 0.05)。 结论 CT能谱成像通过测量肿瘤内碘含量的变化，可以初步评价胰腺癌生物治疗的疗效，为临床上肿瘤治疗效果的判定提供一定的参考价值。
[关键词] CT能谱成像； 胰腺癌； 体层摄影术；X线计算机
[中图分类号] R445.3 [文献标识码] A [文章编号] 1674-4721(2012)04(a)-0013-03
The analysis of biological treatment of pancreatic cancer by the measurement of iodine-based image after spectral CT imaging
LI Hongmin ZHAO Weidong CAI Lin ZHANG Dong YUAN Xiaoxia
Department of Imaging, the Second Hospital Affiliated to Shanxi Medical University, Taiyuan 030001, China
[Abstract] Objective To evaluate the efficacy value of biological treatment of pancreatic cancer, by analysis of spectral CT enhancement imaging before and after the application of this therapy. Methods Twenty cases biological treatment of pancreatic cancer patients were underwent spectral CT enhancement imaging. In gemstone spectral imaging viewer (GSI viewer) software, pancreatic cancer patients were measured the tumor iodine content of before and after biological treatment on the iodine-based image, analysed the variance and paired t-test. Results Twenty patients with pancreatic cancer, biological treatment within the tumor region of interest (ROI) were different between pre-treatment and post-treatment. Iodine content of the tumor in post-treatment was lower than that in pre-treatment (1.89±0.33) vs (3.05±0.42) respectively, t = 19.19, P < 0.05. Conclusion Spectral CT imaging by measuring the changes in iodine content of the tumor, could initially evaluate the efficacy of biological treatment of pancreatic cancer, and could provide a reference value for the clinical efficacy of cancer treatment.
[Key words] Spectral CT imaging; Pancreatic cancer; Tomography; X-ray computer
胰腺癌(pancreatic cancer，PC)是恶性程度很高的肿瘤，因其独特的解剖位置，症状隐匿，早期诊断困难，其根治性切除术后较高的复发与转移率以及对传统化疗、放疗不敏感已成为制约胰腺癌有效治疗的主要障碍[1-2] ......
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